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pentobarbital will decrease the extent or effect of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of abemaciclib with strong CYP3A4 inducers decreases plasma focus of abemaciclib and its metabolites.pentobarbital will minimize the level or outcome of naloxegol by impac